Pharmaceutical Engineering B. Pharm Third Semester PDF Notes

BP 304 T. PHARMACEUTICAL ENGINEERING

 

Scope: This course is designed to impart a fundamental knowledge on the art and science of various unit operations used in pharmaceutical industry.

UNIT-I

Flow of fluids: Types of manometers, Reynolds number and its significance, Bernoulli’s theorem and its applications, Energy losses, Orifice meter, Venturimeter,Pitot tubeand Rotometer.

Size Reduction: Objectives, Mechanisms & Laws governing size reduction, factors affecting size reduction, principles, construction, working, uses, merits and demerits of Hammer mill, ball mill, fluid energy mill, Edge runner mill & end runner mill.

Size Separation:Objectives, applications & mechanism of size separation, official standards of powders, sieves, size separation Principles, construction, working, uses, merits and demerits of Sieve shaker, cyclone separator, Air separator, Bag filter & elutriation tank.

UNIT-II

Heat Transfer: Objectives, applications & Heat transfer mechanisms. Fourier’s law, Heat transfer by conduction, convection & radiation. Heat interchangers & heat exchangers.

Evaporation: Objectives, applications and factors influencing evaporation, differences between evaporation and other heat process. principles, construction, working, uses, merits and demerits of Steam jacketed kettle, horizontal tube evaporator, climbing film evaporator, forced circulation evaporator, multiple effect evaporator& Economy of multiple effect evaporator.

Distillation: Basic Principles and methodology of simple distillation, flash distillation, fractional distillation, distillation under reduced pressure, steam distillation & molecular distillation, Azeotropic Distillation

UNIT- III

Drying: Objectives, applications & mechanism of drying process, measurements & applications of Equilibrium Moisture content, rate of drying curve. principles, construction, working, uses, merits and demerits of Tray dryer, drum dryer, spray dryer, fluidized bed dryer, vacuum dryer, freeze dryer.

Mixing: Objectives, applications & factors affecting mixing, Difference between solid  and  liquid  mixing,  mechanism  of  solid  mixing,  liquids  mixing  and semisolids mixing. Principles, Construction, Working, uses, Merits and Demerits of Double cone blender, twin shell blender, ribbon blender,Sigma blade mixer, planetary mixers, Propellers, Turbines, Paddles & Silverson Emulsifier, Ultrasonic Emulsifier,

UNIT-IV

Filtration: Objectives, applications, Theories & Factors influencing filtration, filter aids, filter medias. Principle, Construction, Working, Uses, Merits and demerits of plate & frame filter, filter leaf,rotary drum filter, Meta filter& Cartridge filter, membrane filters and Seidtz filter.

Centrifugation: Objectives, principle & applications of Centrifugation, principles, construction, working, uses, merits and demerits of Perforated basket centrifuge, Non-perforated basket centrifuge, semi continuous centrifuge & super centrifuge.

 UNIT- V

Materials of pharmaceutical plant construction, Corrosion and its prevention: Factors affecting during materials selected for Pharmaceutical plant construction, Theories of corrosion, types of corrosion and there prevention. Ferrous  and  nonferrous  metals,  inorganic  and  organic  nonmetals,  basic  of material handling systems.