Project report on Trans-dermal Drug Delivery Systems
CONTENTS
1. Introduction
• Advantages
• Limitations of TDD
2. Rising interest in transdermal vaccines
3. Classification for TDDS
• Matrix patches
• Liquid reservoir patches
4. Generation of TDDS
• First generation TDDS
i) Transdermal patch
ii) Transdermal patch design
iii) Stages in Drug Delivery in a Transdermal Patch
• Second generation TDDS
i) Non-cavitational ultrasound
• Third generation TDDS
i) Combinations of chemical enhancers
ii) Biochemical enhancers
iii) Electroporation
iv) Cavitational ultrasound
v) Microneedles
vi) Thermal ablation
vii) Microdermabrasion
viii) Conventional chemical enhancers
5. Representative transdermal drugs in clinical development
6. Human skin
• Percutaneous Absorption
• Transepidermal absorption
• Transfollicular (shunt pathway) absorption
7. Drug penetration
• Routes of drug penetration
• Macro route
• Microroute
• Factor affecting drug penetration
i) Physicochemical properties of the penetrants
ii) Physicochemical properties of drug delivery system
iii) Physiological and pathological conditions of the skin
8. Clearance by local circulation
9. Kinetics of Transdermal Permeation
10. Basic component of TDDS
• Backing Films
• Release Liners
• Pressure-Sensitive Adhesive
• Penetration Enhancers
• Micro porous or Semi-Permeable Membranes
• Pouching Materials
11. Ideal drug candidates for TDDS
12. Designing of TDDS
13. Iontophoresis
• Ideal drug candidates for iontophoresis
• Reverse iontophoresis
14. Future outlook of TDDS
• Microfabricated Microneedle
• Energy Induced
i) Laser Assisted TDDS
ii) Direct Heat Induced Microporation
15. Transdermal product
16. Supersaturated system/crystal reservoir technology
• Sustained Release
• Burst Release
• Chrono-Controlled Release
17. Radiofrequency-driven skin microchonneling
• Transferosomes
18. Approaches used in development of TDDS
• Matrix Systems
• Reservoir Systems
• Micro-Reservoir Systems
19. Production of Transdermal Drug Delivery Systems
• Membrane Permeation Controlled Systems
• Adhesive Dispersion Type Systems
• Matrix Dispersion Type Systems
• Micro-Reservoir Systems
20. Effect Production of Transdermal Drug Delivery Systemsect of hydrophobic permeation enhancer in matrix type TDDS
21. Experiment
• Material
• Preparation of Monolithic Matrix Film
• In vitro Drug Release Study
• Skin Permeation Study
• Results and Discussion
• Skin Permeation
22. Advanced technique for penetration enhanced in TDDS
23. Conclusion
24. References
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