ACECLOFENAC - Uses, Dosage, Pharmacology, Mechanism of Action, Side Effects, Contraindication & Interaction

 ACECLOFANAC 

ACECLOFENAC 

Aceclofenac

•       Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID)

•       Analog of diclofenac

•       It was patented in 1983 and approved for medical use in 1992

USE

•          Rheumatoid Arthritis

•          Osteoarthritis

•          Ankylosing Spondylitis

•          Mild to moderate pain

•          Inflammation

DOSE

•       Adults - The recommended dose is 200 mg daily, taken as two separate 100 mg doses, one tablet in the morning and one in the evening.

•       Paediatric population - It is not recommended for use in children under 18 years of age.

PHARMACOLOGY

•       Absorption - rapidly and completely absorbed from the gastrointestinal tract

•       Volume of distribution – 25L

•       Protein binding - Highly protein-bound (>99%)

•       Route of elimination - urine (70-80%), feces (20%)

•       Half-life - approximately 4 hours

•       Clearance - 5 L/h 

MACHENISM OF ACTION

•       Prostaglandins are substances which is responsible for the sensation of pain, swelling, and inflammation.

•       Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAIDs) and works by blocking the activity of an enzyme that is responsible for the formation of prostaglandins, thus relieving pain, swelling and inflammation.

SIDE EFFECTS

•       Vomiting

•       Stomach pain/epigastric pain

•       Nausea

•       Indigestion

•       Diarrhea

•       Heartburn

•       Loss of appetite

PRECAUTIONS/CONTRAINDICATION

•       Allergies- Avoid if you have a known allergy to Aceclofenac or other ANSIDs.

•       Asthma- Not recommended if you have been diagnosed with asthma.

•       Bleeding - Aceclofenac is not recommended if you have any bleeding disorder. It may cause severe swelling and bleed in the stomach, colon, and anus.

•       Pregnancy- This medicine is not recommended in pregnant women.

•       Breast-nutrition- This medicine is not recommended for breastfeeding women.

•       Gastrointestinal bleeding- Cause severe bleeding when taken for a long time. Elderly populations with a history of gastrointestinal disease are at higher risk.

•       Cardiac surgery- Not be used to relieve pain before or after CABG (coronary artery bypass surgery).

•       Kidney- Not recommended if you have impaired kidney function.

•       Liver- Use with caution with an initial dose of 100 mg once daily for mild liver failure. Contraindicated in the severe failure of the liver.

Interaction with Medicine

•       Corticosteroids – Moderate

•       Antihypertensives – Severe

•       Digoxin– Severe

•       Warfarin– Severe

•       Lithium– Severe

FAMOUS BRANDS

BRAND NAME	COMPANY	MRP
ZERODOL TABLETS	IPCA	51.45
HIFENAC TABLETS	INTAS	52.00
DOLOKIND 100MG TABLETS	MANKIND	32.10
ACECLO TABLETS	ARISTO	48.00
ACENAC TABLETS	MEDLEY	45.50
MOVON TABLETS	IPCA	41.10
DOLOWIN TABLETS	MICRO	51.00
ACENEXT 100MG TABLETS	CADILA	24.50
ACEMIZ 100MG TABLETS	LUPIN	67.00
DOLOSTAT 100MG TABLETS	BLUE CROSS	35.00
EQUIDOL 100MG TABLETS	AKUMENTIS	75.00